Research
ARA-290
An 11-amino-acid peptide taken from the tissue-protective region of erythropoietin, the hormone that drives red blood cell production.
Available in the catalogue
Supplied as research material. Sizes and pricing are on the product page. Availability is not a statement about what a compound does.
What is being investigated
Directions the published work points at, and how far each has actually got. These are open questions, not established effects: most of what looks promising in cells does not replicate in animals, and most of what works in animals does not work in people. Nothing here is a claim about what this compound does for anyone.
- Small-fibre neuropathy
Its main clinical direction. Randomised trials in sarcoidosis and in type 2 diabetes measured neuropathic symptoms and metabolic control; the trials are small by the standards of the metabolic compounds elsewhere in this catalogue.
Human trials
- Corneal nerve fibre regeneration
Corneal confocal microscopy gives a directly countable measure of small nerve fibres, which is why it appears as an endpoint in this literature rather than as a target in itself.
Human trials
- Tissue protection without raising red cell count
The design question. Erythropoietin's two activities run through different receptors, and this fragment engages only the repair one — so the thing being tested is whether the protective half survives the separation.
Animal studies
Published research
Every reference below was checked against the published record before being listed, with the model each study used.
- Brines et al. (2015)Molecular Medicine
Reported changes in metabolic control and neuropathic symptoms in participants with type 2 diabetes.
human, randomised controlled Source
Further reading
Longer articles on handling, analysis and what the published work reports.
- ARA-290 (cibinetide): what the research says
An erythropoietin fragment engineered to keep the tissue protection and drop the red-cell activity, with a published randomised trial in type 2 diabetes.
- How to store research peptides
Lyophilised peptides at -20°C, reconstituted at 2–8°C, ambient in transit. Why the dry cake tolerates shipping, and what actually degrades a vial.
- Peptide shelf life and stability
How long lyophilised and reconstituted peptides keep, and the four things that shorten it: temperature, moisture, light and oxidation. Storage figures included.
- How to reconstitute lyophilised peptides
How to reconstitute a lyophilised peptide with bacteriostatic water without damaging it: why you run the liquid down the vial wall and never shake it.