Research
CJC-1295 no-DAC
A 29-amino-acid analogue of growth hormone-releasing hormone, with four amino acid substitutions that resist enzymatic breakdown. The no-DAC form omits the drug affinity complex that binds albumin.
Available in the catalogue
Supplied as research material. Sizes and pricing are on the product page. Availability is not a statement about what a compound does.
What is being investigated
Directions the published work points at, and how far each has actually got. These are open questions, not established effects: most of what looks promising in cells does not replicate in animals, and most of what works in animals does not work in people. Nothing here is a claim about what this compound does for anyone.
- Growth hormone and IGF-1 elevation
Dose-dependent increases in both were reported in healthy adults — with the DAC form, whose half-life runs to days. The no-DAC form has no equivalent published trial of its own.
Human trials
- Whether the natural pulse pattern matters
The question this version exists to ask. Removing the albumin-binding linker drops the half-life to roughly half an hour, so growth hormone rises in pulses rather than continuously; whether that difference changes any outcome has not been tested.
Proposed from mechanism
- Pairing with a ghrelin-receptor secretagogue
GHRH analogues and GHRPs reach the pituitary through different receptors, which is the usual stated rationale for combining them. No trial has compared the pair against either component alone.
Proposed from mechanism
Published research
Every reference below was checked against the published record before being listed, with the model each study used.
- Teichman et al. (2006)Journal of Clinical Endocrinology & Metabolism · 91(3):799–805
Reported dose-dependent increases in growth hormone and IGF-1 in healthy adults, sustained over several days.
human, randomised placebo-controlled (CJC-1295 with DAC) Source
Further reading
Longer articles on handling, analysis and what the published work reports.
- CJC-1295 (Mod GRF 1-29): what the research says
The best-known CJC-1295 human trial studied the DAC form, not the no-DAC form sold as Mod GRF 1-29. Why the two have very different pharmacokinetics.
- How to store research peptides
Lyophilised peptides at -20°C, reconstituted at 2–8°C, ambient in transit. Why the dry cake tolerates shipping, and what actually degrades a vial.
- Peptide shelf life and stability
How long lyophilised and reconstituted peptides keep, and the four things that shorten it: temperature, moisture, light and oxidation. Storage figures included.
- How to reconstitute lyophilised peptides
How to reconstitute a lyophilised peptide with bacteriostatic water without damaging it: why you run the liquid down the vial wall and never shake it.