Research
HMG
A preparation purified from human urine, containing both follicle-stimulating hormone and luteinising hormone activity in roughly equal measure.
Available in the catalogue
Supplied as research material. Sizes and pricing are on the product page. Availability is not a statement about what a compound does.
What is being investigated
Directions the published work points at, and how far each has actually got. These are open questions, not established effects: most of what looks promising in cells does not replicate in animals, and most of what works in animals does not work in people. Nothing here is a claim about what this compound does for anyone.
- Controlled ovarian stimulation
Its established use, and the setting nearly all of its trial evidence comes from. Long-standing clinical practice rather than an open research direction.
Human trials
- Whether LH activity adds anything to FSH alone
The question that separates it from recombinant single-hormone preparations, addressed in randomised comparisons with results that have not settled it either way.
Human trials
- Spermatogenesis in hypogonadotropic hypogonadism
Supplying FSH activity where the pituitary supplies none, usually alongside an LH-receptor agonist. Established, though on a much smaller evidence base than the ovarian work.
Human trials
- What is actually in the preparation
A standing question about any purified extract rather than a hoped-for effect: composition varies between preparations, which is a meaningful difference from a synthesised peptide.
Proposed from mechanism
Published research
Every reference below was checked against the published record before being listed, with the model each study used.
- Al-Inany et al. (2008)Reproductive BioMedicine Online · 16(1):81–8
Pooled randomised comparisons of human menopausal gonadotrophins against recombinant FSH, reporting on efficacy and safety across the trials available at the time.
human, meta-analysis of randomised trials Source
- Jee et al. (2010)Gynecologic and Obstetric Investigation · 70(2):132–7
Compared highly purified hMG against recombinant FSH in IVF and ICSI cycles, examining clinical efficacy across the pooled trials.
human, meta-analysis of randomised trials Source
Further reading
Longer articles on handling, analysis and what the published work reports.
- HMG (menotropins): what the research says
A urine-derived preparation carrying both FSH and LH activity. What the long-running head-to-head trials against recombinant FSH actually found.
- How to store research peptides
Lyophilised peptides at -20°C, reconstituted at 2–8°C, ambient in transit. Why the dry cake tolerates shipping, and what actually degrades a vial.
- Peptide shelf life and stability
How long lyophilised and reconstituted peptides keep, and the four things that shorten it: temperature, moisture, light and oxidation. Storage figures included.
- How to reconstitute lyophilised peptides
How to reconstitute a lyophilised peptide with bacteriostatic water without damaging it: why you run the liquid down the vial wall and never shake it.