Research
IGF-1 LR3
A recombinant analogue of insulin-like growth factor 1, with a 13-residue extension at the N-terminus and arginine substituted for glutamic acid at position 3.
Available in the catalogue
Supplied as research material. Sizes and pricing are on the product page. Availability is not a statement about what a compound does.
What is being investigated
Directions the published work points at, and how far each has actually got. These are open questions, not established effects: most of what looks promising in cells does not replicate in animals, and most of what works in animals does not work in people. Nothing here is a claim about what this compound does for anyone.
- IGF-1 signalling without binding-protein interference
What the analogue was actually built for. Binding proteins confound IGF-1 experiments in culture, and cutting that affinity roughly a thousandfold is what lets the receptor's own contribution be read.
Cell and tissue studies
- Cell-line productivity in bioprocessing
Used as a serum-free medium supplement in industrial cell culture, where the question being asked is yield rather than physiology.
Cell and tissue studies
- Muscle and tissue growth
IGF-1 is the growth factor much of growth hormone's effect runs through, and animal work examines what happens when far more of it is available unbound. No human trial has been published on this analogue.
Animal studies
Published research
Every reference below was checked against the published record before being listed, with the model each study used.
- Francis et al. (1992)Journal of Molecular Endocrinology · 8(3):213–23
Compared IGF-1 analogues to establish the relative contribution of binding-protein affinity and receptor affinity to biological potency.
in vitro, recombinant analogues Source
Further reading
Longer articles on handling, analysis and what the published work reports.
- IGF-1 LR3 (Long R3 IGF-1): what the research says
An analogue engineered to evade the binding proteins that regulate natural IGF-1 — which is exactly why it is a cell-culture reagent, and why that matters.
- How to store research peptides
Lyophilised peptides at -20°C, reconstituted at 2–8°C, ambient in transit. Why the dry cake tolerates shipping, and what actually degrades a vial.
- Peptide shelf life and stability
How long lyophilised and reconstituted peptides keep, and the four things that shorten it: temperature, moisture, light and oxidation. Storage figures included.
- How to reconstitute lyophilised peptides
How to reconstitute a lyophilised peptide with bacteriostatic water without damaging it: why you run the liquid down the vial wall and never shake it.