Research
NAD+
Not a peptide but a coenzyme, present in every cell, central to how cells move electrons during energy metabolism.
Available in the catalogue
Supplied as research material. Sizes and pricing are on the product page. Availability is not a statement about what a compound does.
What is being investigated
Directions the published work points at, and how far each has actually got. These are open questions, not established effects: most of what looks promising in cells does not replicate in animals, and most of what works in animals does not work in people. Nothing here is a claim about what this compound does for anyone.
- Whether cellular NAD+ can be raised at all
The question everything else depends on, and the one with human data. Oral precursors produced dose-dependent increases in the blood NAD+ metabolome; the intact coenzyme is poorly taken up by cells, which is why the trials use precursors.
Human trials
- Sirtuin- and PARP-dependent processes in ageing
NAD+ is the required substrate for both enzyme families, and levels fall with age. Whether raising the substrate restores what the enzymes do is the actual hypothesis, and it is an animal-stage one.
Animal studies
- Neuroprotection and axon survival
A separate strand, built on the finding that axon degeneration after injury runs through NAD+ depletion rather than alongside it. Studied in animal and cell models of nerve injury.
Animal studies Cell and tissue studies
- Whether a measurable rise changes any outcome
The gap between the first item and the second. Trials show the number can be moved; whether moving it does anything a person would notice has not been demonstrated in a controlled human trial.
Proposed from mechanism
Published research
Every reference below was checked against the published record before being listed, with the model each study used.
- Trammell et al. (2016)Nature Communications · 7:12948
Reported that single oral doses produced dose-dependent increases in the blood NAD+ metabolome, with a rise of up to 2.7-fold in a single-participant pilot in the same paper.
mouse and human, oral nicotinamide riboside Source
Further reading
Longer articles on handling, analysis and what the published work reports.
- NAD+, NR and NMN: what the research says
Almost all human NAD+ evidence is about oral precursors, not NAD+ itself, because cells take up the intact molecule poorly. The two are not interchangeable.
- How to store research peptides
Lyophilised peptides at -20°C, reconstituted at 2–8°C, ambient in transit. Why the dry cake tolerates shipping, and what actually degrades a vial.
- Peptide shelf life and stability
How long lyophilised and reconstituted peptides keep, and the four things that shorten it: temperature, moisture, light and oxidation. Storage figures included.
- How to reconstitute lyophilised peptides
How to reconstitute a lyophilised peptide with bacteriostatic water without damaging it: why you run the liquid down the vial wall and never shake it.