Research
PE-22-28
A seven-amino-acid fragment of spadin, itself a peptide released during the maturation of the sortilin propeptide.
Available in the catalogue
Supplied as research material. Sizes and pricing are on the product page. Availability is not a statement about what a compound does.
What is being investigated
Directions the published work points at, and how far each has actually got. These are open questions, not established effects: most of what looks promising in cells does not replicate in animals, and most of what works in animals does not work in people. Nothing here is a claim about what this compound does for anyone.
- TREK-1 blockade as an antidepressant mechanism
The reason the channel is a target: deleting it in mice produces a depression-resistant phenotype. Blocking it pharmacologically is studied in rodent behavioural models, which are a weak proxy for the condition.
Animal studies
- Speed of onset
What would make the mechanism interesting if it held. Monoamine antidepressants take weeks; effects in the rodent models here are reported over days. A timescale in mice is not a timescale in people.
Animal studies
- Anything in humans
There is no published human work on this peptide. The references below concern cell and rodent studies, which do not establish effects in people.
Proposed from mechanism
Published research
Every reference below was checked against the published record before being listed, with the model each study used.
- Djillani et al. (2017)Frontiers in Pharmacology · 8:643
Reported that shortened spadin analogues displayed better TREK-1 inhibition, greater in-vivo stability and antidepressant-like activity in rodent behavioural models than spadin itself.
mouse and in vitro Source
- Mazella et al. (2018)Frontiers in Pharmacology · 9:1541
Reviewed the role of sortilin/NTSR3 as the progenitor of spadin and its involvement in the membrane expression of TREK-1.
review of in vitro and rodent work Source
Further reading
Longer articles on handling, analysis and what the published work reports.
- PE-22-28 (spadin analogue): what the research says
A TREK-1 blocker that came out of mouse genetics rather than drug screening, putting it outside the monoamine story entirely. All of it is preclinical.
- How to store research peptides
Lyophilised peptides at -20°C, reconstituted at 2–8°C, ambient in transit. Why the dry cake tolerates shipping, and what actually degrades a vial.
- Peptide shelf life and stability
How long lyophilised and reconstituted peptides keep, and the four things that shorten it: temperature, moisture, light and oxidation. Storage figures included.
- How to reconstitute lyophilised peptides
How to reconstitute a lyophilised peptide with bacteriostatic water without damaging it: why you run the liquid down the vial wall and never shake it.